Carroll lab
Publications
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2024
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The role of nutrient sensing dysregulation in anorexia of ageing: The little we know and the much we don’t.
Dagbasi A, Fuller A, Hanyaloglu A C, Carroll B, McLaughlin J, Frost G, et al. Appetite. 2024; 203, 107718.
https://doi.org/10.1016/j.appet.2024.107718
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Senescence in the ageing skin: a new focus on mTORC1 and the lysosome.
Smith P & Carroll B. Febs J. 2024
https://doi.org/10.1111/febs.17281
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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, et al. Dev Cell. 2024; 59(15), 1924-1939 e1927.
https://doi.org/10.1016/j.devcel.2024.04.020
Augmented gut hormone response to feeding in older adults exhibiting low appetite.
Dagbasi A, Warner J, Catterall V, Smith K, Crabtree D R, Carroll B, et al. Appetite. 2024; 201, 107415.
https://doi.org/10.1016/j.appet.2024.107415
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2023
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TFEB-dependent lysosome biogenesis is required for senescence.
Curnock R, Yalci K, Palmfeldt J, Jäättelä M, Liu B, Carroll B. Embo J. 2023;42(9).
https://doi.org/10.15252/embj.2022111241
2022
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NDP52 acts as a redox sensor in PINK1/Parkin-mediated mitophagy.
Kataura T, Otten EG, Rabanal-Ruiz Y, Adriaenssens E, Urselli F, Scialo F, et al. Embo J. 2022;42(5).
https://doi.org/10.15252/embj.2022111372
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2021
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Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, et al. Embo J. 2021;40(9).
https://doi.org/10.15252/embj.2020106048
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mTORC1 activity is supported by spatial association with focal adhesions.
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, et al. J Cell Biol. 2021;220(5).
https://doi.org/10.1083/jcb.202004010
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Sandoval MC, De Meulemeester AS, Baumeister R, Brohée L, et al. Cell. 2021;184(3):655-+.
https://doi.org/10.1016/j.cell.2020.12.024​​
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2020​​
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Spatial regulation of mTORC1 signalling: Beyond the Rag GTPases.
Carroll B. Semin Cell Dev Biol. 2020;107:103-11.
https://doi.org/10.1016/j.semcdb.2020.02.007
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2019
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PCV2 replication promoted by oxidative stress is dependent on the regulation of autophagy on apoptosis.
Zhai NH, Liu K, Li H, Liu ZX, Wang H, Korolchuk VI, et al. Vet Res. 2019;50.
https://doi.org/10.1186/s13567-019-0637-z
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The mTORC1-autophagy pathway is a target for senescent cell elimination.
Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. Biogerontology. 2019;20(3):331-5.
https://doi.org/10.1007/s10522-019-09802-9​
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Rapamycin improves healthspan but not inflammaging in mice.
Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, et al. Aging Cell. 2019;18(1).
https://doi.org/10.1111/acel.12882
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2018
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Nutrient sensing, growth and senescence.
Carroll B, Korolchuk VI. Febs J. 2018;285(11):1948-58.
https://doi.org/10.1111/febs.14400
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Oxidation of p62 as an evolutionary adaptation to promote autophagy in stress conditions.
Otten E G, Stefanatos R, Carroll B, & Korolchuk V I. Cell Stress. 2018;2(4), 91-93.
https://doi.org/10.15698/cst2018.04.132
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Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.
Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, et al. Nat Commun. 2018;9.
https://doi.org/10.1038/s41467-017-02746-z​
2017
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Dysregulation of mTORC1/autophagy axis in senescence.
Carroll B, Korolchuk VI. Aging-Us. 2017;9(8):1851-2.
https://doi.org/10.18632/aging.101277
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Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
Korolchuk VI, Miwa S, Carroll B, von Zglinicki T. Ebiomedicine. 2017;21:7-13.
https://doi.org/10.1016/j.ebiom.2017.03.020
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Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, et al. J Cell Biol. 2017;216(7):1949-57.
https://doi.org/10.1083/jcb.201610113
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The lysosome: a crucial hub for AMPK and mTORC1 signalling.
Carroll B, Dunlop EA. Biochem J. 2017;474(9):1453-66.
https://doi.org/10.1042/Bcj20160780
2016
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SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.
Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, et al. Autophagy. 2016;12(10):1917-30.
https://doi.org/10.1080/15548627.2016.1210368
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Autophagy, lipophagy and lysosomal lipid storage disorders.
Ward C, Martinez-Lopez N, Otten EG, Carroll B, Maetzel D, Singh R, et al. Bba-Mol Cell Biol L. 2016;1861(4):269-84.
https://doi.org/10.1016/j.bbalip.2016.01.006​
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Mitochondria are required for pro-ageing features of the senescent phenotype.
Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, et al. Embo J. 2016;35(7):724-42.
https://doi.org/10.15252/embj.201592862
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky D J, Abdelmohsen K, Abe A, Abedin M J, Abeliovich H, Acevedo Arozena A, et al (>1000 authors). Autophagy. 2016;12(1), 1-222.
https://doi.org/10.1080/15548627.2015.1100356
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Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.
Carroll B, Maetzel D, Maddocks ODK, Otten G, Ratcliff M, Smith GR, et al. Elife. 2016;5.
https://doi.org/10.7554/eLife.11058
2015
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Chapter 5 - Mechanisms of Cross-Talk between Intracellular Protein Degradation Pathways.
Hewitt G, Carroll B, Korolchuk VI. In: Hayat MA, editor. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Amsterdam: Academic Press; 2015. p. 103-19.
https://doi.org/https://doi.org/10.1016/B978-0-12-801032-7.00005-8
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Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis.
Carroll B, Korolchuk VI, Sarkar S. Amino Acids. 2015;47(10):2065-88.
https://doi.org/10.1007/s00726-014-1775-2
2014
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Dual proteolytic pathways govern glycolysis and immune competence.
Lu W, Zhang Y, McDonald DO, Jing H, Carroll B, Robertson N, et al. Cell. 2014;159(7):1578-90.
https://doi.org/10.1016/j.cell.2014.12.001
2013
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Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.
Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, et al. Cell Rep. 2013;5(5):1302-15.
https://doi.org/10.1016/j.celrep.2013.10.042​
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Autophagy and ageing: implications for age-related neurodegenerative diseases.
Carroll B, Hewitt G, Korolchuk VI. Essays Biochem. 2013;55:119-31.
https://doi.org/10.1042/bse0550119
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The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy.
Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, et al. Dev Cell. 2013;25(1):15-28.
https://doi.org/10.1016/j.devcel.2013.03.005
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2009
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Epidemics of squirrelpox virus disease in red squirrels ( Sciurus vulgaris): temporal and serological findings.
Carroll B, Russell P, Gurnell J, Nettleton P, Sainsbury AW. Epidemiol Infect. 2009;137(2):257-65.
https://doi.org/10.1017/S0950268808000836
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