For a full list of publications, see here:
http://www.bris.ac.uk/biochemistry/people/bernadette-m-carroll/publications.html
Selected Publications:
.
2020
Carroll, B 2020, 'Spatial regulation of mTORC1 signalling: Beyond the Rag GTPases' .Seminars in Cell & Developmental Biology
2019
Correia-Melo, C, Birch, J, Fielder, E, Rahmatika, D, Taylor, J, Chapman, J, Lagnado, A, Carroll, BM, Miwa, S, Richardson, G, Jurk, D, Oakley, F, Mann, J, Mann, DA, Korolchuk, VI & Passos, JF, 2019, ‘Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice’. Aging Cell, vol 18
https://doi.org/10.1111/acel.12882
Kucheryavenko, O, Nelson, G, von Zglinicki, T, Korolchuk, VI & Carroll, B, 2019, ‘The mTORC1-autophagy pathway is a target for senescent cell elimination’. Biogerontology.
2018
Carroll, B, Otten, EG, Manni, D, Stefanatos, R, Menzies, FM, Smith, GR, Jurk, D, Kenneth, N, Wilkinson, S, Passos, JF, Attems, J, Veal, EA, Teyssou, E, Seilhean, D, Millecamps, S, Eskelinen, EL, Bronowska, AK, Rubinsztein, DC, Sanz, A & Korolchuk, VI, 2018, ‘Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis’. Nature Communications, vol 9
https://www.nature.com/articles/s41467-017-02746-z
Carroll, B & Korolchuk, VI, 2018, ‘Nutrient sensing, growth and senescence’. FEBS Journal, vol 285., pp. 1948-1958
2017
Carroll, B & Korolchuk, VI, 2017, ‘Dysregulation of mTORC1/autophagy axis in senescence’. Aging, vol 9., pp. 1851-1852
https://doi.org/10.18632/aging.101277
Carroll, B*, Nelson, G, Rabanal-Ruiz, Y, Kucheryavenko, O, Dunhill-Turner, NA, Chesterman, CC, Zahari, Q, Zhang, T, Conduit, SE, Mitchell, CA, Maddocks, OD, Lovat, P, von Zglinicki, T & Korolchuk, VI*, 2017, Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing’. Journal Cell Biology 216 No. 7 1949–1957* co-corresponding author
https://doi.org/10.1083/jcb.201610113
Carroll, B & Dunlop, EA, 2017, ‘The lysosome: A crucial hub for AMPK and mTORC1 signalling’. Biochemical Journal, vol 474., pp. 1453-1466
https://doi.org/10.1042/BCJ20160780
Korolchuk, VI, Miwa, S, Carroll, B & von Zglinicki, T, 2017, ‘Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?’. EBioMedicine, vol 21., pp. 7-13
2016
Hewitt, G., Carroll, B., Sarallah, R., Correia-Melo, C., Ogrodnik, M., Nelson, G., Otten, E. G., Manni, D., Antrobus, R., Morgan, B. A., von Zglinicki, T., Jurk, D., Seluanov, A., Gorbunova, V., Johansen, T., Passos, J. F. & Korolchuk, V. I., 2016, SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 12, 10, p.1917-1930
https://doi.org/10.1080/15548627.2016.1210368
Ward, C., Martinez-Lopez, N., Otten, E. G., Carroll, B., Maetzel, D., Singh, R., Sarkar, S. & Korolchuk, V. I., 2016, Autophagy, lipophagy and lysosomal lipid storage disorders. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861, 4, p.269-284
https://doi.org/10.1016/j.bbalip.2016.01.006
Correia-Melo, C., Marques, F. D. M., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., Rushton, M. D., Charles, M., Jurk, D., Tait, S. W. G., Czapiewski, R., Greaves, L., Nelson, G., Bohlooly-Y, M., Rodriguez-Cuenca, S., Vidal-Puig, A. et al, 2016, Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO Journal. 35, 7, p.724-742
https://doi.org/10.15252/embj.201592862
Carroll, B., Maetzel, D., Maddocks, O. D. K., Otten, G., Ratcliff, M., Smith, G. R., Dunlop, E. A., Passos, J. F., Davies, O. R., Jaenisch, R., R.Tee, A., Sarkar, S. & Korolchuk, V. I., 2016, Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity . eLife. e11058
2014
Lu, W., Zhang, Y., McDonald, D. O., Jing, H., Carroll, B., Robertson, N., Zhang, Q., Griffin, H., Sanderson, S., Lakey, J. H., Morgan, N. V., Reynard, L. N., Zheng, L., Murdock, H. M., Turvey, S. E., Hackett, S. J., Prestidge, T., Hall, J. M., Cant, A. J., Matthews, H. F. et al, 2014, Dual proteolytic pathways govern glycolysis and immune competence. Cell, 159, 7, p.1578-1590
2013
Sarkar, S., Carroll, B., Buganim, Y., Maetzel, D., Ng, A. H. M., Cassady, J. P., Cohen, M. A., Chakraborty, S., Wang, H., Spooner, E., Ploegh, H., Gsponer, J., Korolchuk, V. I. & Jaenisch, R., 2013, Impaired autophagy in the lipid-storage disorder niemann-pick type c1 disease. Cell Reports. 5, 5, p.1302-1315
https://doi.org/10.1016/j.celrep.2013.10.042
Carroll, B., Hewitt, G. & Korolchuk, V. I., 2013, Autophagy and ageing: Implications for age-related neurodegenerative diseases. Essays in Biochemistry. 55, 1, p.119-131
https://doi.org/10.1042/BSE0550119
Carroll, B., Mohd-Naim, N., Maximiano, F., Frasa, M. A., McCormack, J., Finelli, M., Thoresen, S. B., Perdios, L., Daigaku, R., Francis, R. E., Futter, C., Dikic, I. & Braga, V. M. M., The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy 2013, Developmental Cell. 25, 1, p.15-28